Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs110402
rs110402
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0008060
Disease:
child abuse behavior
0.030 GeneticVariation BEFREE While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger symptom reduction in a subset of patients with probable CRF system hyperactivity, i.e., patients with child abuse and CRHR1 SNP rs110402 GG carriers. 30390684 2018
dbSNP: rs17689918
rs17689918
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0003467
Disease:
Anxiety
0.010 GeneticVariation BEFREE When investigating neural correlates underlying this association in patients with PD using functional magnetic resonance imaging, risk allele carriers of rs17689918 showed aberrant differential conditioning predominantly in the bilateral prefrontal cortex and safety signal processing in the amygdalae, arguing for predominant generalization of fear and hence anxious apprehension. 26324098 2016
dbSNP: rs242941
rs242941
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0011581
Disease:
Depressive disorder
0.030 GeneticVariation BEFREE When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043). 26518448 2015
dbSNP: rs242941
rs242941
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0011570
Disease:
Mental Depression
0.020 GeneticVariation BEFREE When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043). 26518448 2015
dbSNP: rs242941
rs242941
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0344315
Disease:
Depressed mood
0.020 GeneticVariation BEFREE When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043). 26518448 2015
dbSNP: rs242941
rs242941
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0004936
Disease:
Mental disorders
0.010 GeneticVariation BEFREE When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043). 26518448 2015
dbSNP: rs16940665
rs16940665
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs16940668
rs16940668
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs16940674
rs16940674
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs16940676
rs16940676
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs17425752
rs17425752
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs1876828
rs1876828
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs1876829
rs1876829
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs1876830
rs1876830
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs2316765
rs2316765
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs4482334
rs4482334
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs4525537
rs4525537
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs878887
rs878887
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs878888
rs878888
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0030567
Disease:
Parkinson Disease
0.700 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs110402
rs110402
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0008060
Disease:
child abuse behavior
0.030 GeneticVariation BEFREE We then extended our previously reported interaction with both a CRHR1 SNP (rs110402) and TCA haplotype interacting with child abuse to predict current symptoms (N = 1,059; P = 0.0089). 20029939 2010
dbSNP: rs110402
rs110402
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0003469
Disease:
Anxiety Disorders
0.030 GeneticVariation BEFREE We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). 23274505 2013
dbSNP: rs110402
rs110402
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0003467
Disease:
Anxiety
0.020 GeneticVariation BEFREE We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). 23274505 2013
dbSNP: rs7209436
rs7209436
Entrez Id: 1394;104909134
Gene Symbol: CRHR1;LINC02210-CRHR1
CRHR1;LINC02210-CRHR1
CUI: C0003469
Disease:
Anxiety Disorders
0.010 GeneticVariation BEFREE We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). 23274505 2013
dbSNP: rs7209436
rs7209436
Entrez Id: 1394;104909134
Gene Symbol: CRHR1;LINC02210-CRHR1
CRHR1;LINC02210-CRHR1
CUI: C0003467
Disease:
Anxiety
0.010 GeneticVariation BEFREE We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). 23274505 2013
dbSNP: rs17689918
rs17689918
Entrez Id: 1394;100128977;104909134
Gene Symbol: CRHR1;MAPT-AS1;LINC02210-CRHR1
CRHR1;MAPT-AS1;LINC02210-CRHR1
CUI: C0233523
Disease:
Antisocial behavior
0.010 GeneticVariation BEFREE We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors. 29772307 2018